- Degree Bachelor
- Code: PD215
- Credit hrs: 3
- Prequisites: PD117
This course covers the structure and function of the skin, the target area of treatment after topical application to the skin, basic principles of diffusion through membranes and factors affecting percutaneous absorption, enhancement of skin penetration, and transdermal drug delivery systems (TDDS). It also describes the principles and techniques involved in the formulation and manufacturing of traditional dermatological semisolid dosage forms (creams, ointments, gels, pastes) and cosmetic products, in addition to the preparation and stabilization of other semisolid preparations such as suppositories and pessaries. The course also aims to provide students with broad knowledge of the various types of vehicles, bases, and emulsifiers used in their preparation and their effect on dosage form stability.
Bachelor of Pharmacy - PharmD
1.1 Demonstrate understanding of knowledge of semisolid pharmaceutical dosage forms.
1.2 Utilize the proper pharmaceutical terms, abbreviations and symbols in pharmacy practice.
1.3 Integrate knowledge from fundamental sciences to handle, design, prepare and assure quality of semisolid pharmaceutical products (e.g., ointments, creams, gels, suppositories)
1.4 Identify and critically analyze newly emerging issues influencing the pharmaceutical industry.
2.1 Apply the basic requirements of a quality control system to evaluate and characterize semisolid dosage forms.
2.2 Recognize the principles of various instruments and select the proper techniques for synthesis of different semisolid dosage forms
2.3 Adopt the principles of pharmaceutical calculations for semisolid preparations
2.4 Design different semisolid dosage form prescriptions.
3.1 Educate and counsel patients about the safe and proper use of semisolid preparations, especially OTC preparations, and some medical devices used for transdermal drug delivery.
3.2 Maintain public awareness of the social health hazards of drug misuse and abuse
4.1 Demonstrate responsibility for team performance and peer evaluation of other team members, and express time management skills.
4.2 Retrieve and critically analyze information, identify and solve problems, and work autonomously and effectively in a team.
4.3 Use new technologies and media to demonstrate effective presentation skills.
4.4 Practice independent learning needed for continuous professional development.
Allen, Loyd V. Jr., and Timothy B. McPherson. Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems, 12th ed. 2023.
| content serial | Description |
|---|---|
| 1 | Introduction to semisolid preparations (Lecture) |
| 1 | Good compounding practice & overview of semisolid dosage forms compounding. (Practical) |
| 2 | Classification of semisolid dosage forms; routes of topical drug penetration (Lecture) |
| 2 | Calculations for ointment, cream and paste compounding. (Practical) |
| 3 | Routes of topical drug penetration (cont.) (Lecture) |
| 3 | White ointment compounding.(Practical) |
| 4 | Composition of semisolid preparations (Lecture) |
| 4 | Preparation of Lassar’s paste. (Practical) |
| 5 | Pharmaceutical manufacture of semisolid preparations (ointments and pastes). (Lecture) |
| 5 | Zinc oxide ointment compounding. (Practical) |
| 6 | Ophthalmic ointments and patient counseling. (Lecture) |
| 6 | Sulfur ointment compounding.(Practical) |
| 7 | Pharmaceutical manufacture of semisolid preparations (creams & gels). (Lecture) |
| 7 | Preparation of cold cream.(Practical) |
| 8 | Packaging materials and quality control tests of semisolid preparations.(Lecture) |
| 8 | Preparation of vanishing cream.(Practical) |
| 9 | New trends in enhancing transdermal drug delivery. (Lecture) |
| 9 | Calculations for suppositories compounding (density, volume, and displacement factor).(Practical) |
| 10 | Introduction to suppositories (different types). (Lecture) |
| 10 | Preparation of zinc oxide cocoa butter suppository.(Practical) |
| 11 | Composition of different types of suppositories. (Lecture) |
| 11 | Compounding of resorcinol Witepsol suppository. (Practical) |
| 12 | Pharmaceutical manufacturing of suppositories on small and large scale. (Lecture) |
| 12 | Preparation of potassium iodide Witepsol suppositories.(Practical) |
| 13 | Packaging material of suppositories. (Lecture) |
| 13 | Preparation of aminophylline PEG suppositories. (Practical) |
| 14 | Quality control testing of suppositories. (Lecture) |
| 14 | Preparation of zinc oxide gelatin glycerin pessaries. (Practical) |
| 15 | Problems in formulating suppositories. (Lecture) |
| 15 | Students’ presentations on selected semisolid dosage forms prescriptions. (Practical) |
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