- Degree Bachelor
- Code: PD416
- Credit hrs: 2
- Prequisites: PD316
The course aims to provide students with insights and competencies related to the principles of pharmaceutical pre-formulation as a gateway to dosage forms design and formulation. Emphasis is placed on developing formulations based on the physical and chemical properties of the drug substance and the intended use of the drug product. The course also introduces the students to the formulation principles and applications of novel and targeted drug delivery systems by transforming proteins, genes, and other biotechnology driven compounds into therapeutic products. In addition to formulation aspects of biotechnology derived pharmaceuticals, it also covers the application of polymers and excipients to solve problems/issues concerning the optimization of absorption, selective transport, and targeting.
Bachelor of Pharmacy - PharmD
1.1 Explain the principles and mechanisms of advanced drug delivery and targeting systems.
1.2 Compare advanced dosage forms and routes of drug administration.
1.3 Explain controlled-release, targeting, and bio-responsive drug delivery mechanisms.
1.4 Describe current and emerging technologies for oral, transmucosal, nasal, pulmonary, ocular, and CNS drug delivery.
2.1 Evaluate advanced drug delivery systems with consideration of safety, biocompatibility, and potential adverse effects.
2.2 Apply professional judgment in selecting appropriate drug delivery technologies based on therapeutic and patient-related considerations.
4.2 Demonstrate independent learning and problem-solving in evaluating emerging drug delivery technologies.
3.2 Explain the contribution of advanced drug delivery systems to therapeutic effectiveness, patient adherence, and reduction of undesirable drug exposure.
4.1 Critically analyze and communicate the scientific principles underlying advanced drug delivery technologies.
3.1 Select appropriate drug delivery systems according to drug properties, therapeutic objectives, and physiological barriers.
Aulton, Michael E., and Kevin MG Taylor. Aulton's pharmaceutics: the design and manufacture of medicines. Elsevier Health Sciences, 2018.
| content serial | Description |
|---|---|
| 1 | Introduction to advanced drug delivery systems. (Lecture) |
| 1 | Introduction to advanced drug delivery systems.(Practical) |
| 2 | Terminology of drug delivery and targeting.(Lecture) |
| 2 | Buccal drug delivery. (Practical) |
| 3 | Dosage forms for advanced drug delivery and targeting and routes of administration. (Lecture) |
| 3 | Gastro-retentive dosage forms. (Practical) |
| 4 | Fundamentals of implantable systems.(Lecture) |
| 4 | Micro- and Nanoemulsions formulation. (Practical) |
| 5 | Applications of implantable systems. (Lecture) |
| 5 | Self micro-emulsifying and self nano-emulsifying drug delivery systems. (Practical) |
| 6 | Fundamentals of parenteral targeted drug delivery. (Lecture) |
| 6 | Lipid based drug delivery systems (Liposomes). (Practical) |
| 7 | Applications of parenteral targeted drug delivery. (Lecture) |
| 7 | Lipid based drug delivery systems (SLN and NLC). (Practical) |
| 8 | Current and new emerging technologies in oral drug delivery. (Lecture) |
| 8 | Nano-based drug delivery systems (Niosomes and Proniosomes).(Practical) |
| 9 | Current and new emerging technologies in oral transmucosal drug delivery. (Lecture) |
| 9 | Introduction to polymeric nanoparticles. (Practical) |
| 10 | Current and new emerging technologies in transdermal drug delivery. (Lecture) |
| 10 | Polymeric nanoparticles (Nanocapsules and Nanospheres). (Practical) |
| 11 | Current and new emerging technologies in nasal drug delivery. (Lecture) |
| 11 | Vesicular drug delivery systems (Transferosomes). (Practical) |
| 12 | Current and new emerging technologies in pulmonary drug delivery. (Lecture) |
| 12 | Vesicular drug delivery systems (Cubosomes). (Practical) |
| 13 | Current and new emerging technologies in vaginal and ophthalmic drug delivery. (Lecture) |
| 13 | Vesicular drug delivery systems (Ethosomes and Chitosomes). (Practical) |
| 14 | Current and new emerging technologies in CNS drug delivery. (Lecture) |
| 14 | Hydrogels formulation. (Practical) |
| 15 | Current and new emerging technologies in gene delivery. (Lecture) |
| 15 | Dendrimers formulation. (Practical) |
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