- Degree Bachelor
- Code: PD515
- Credit hrs: 3
- Prequisites: PD512
This course is a continuation of the study of the various unit operations in pharmaceutical industry with emphasis on size reduction, size separation, size analysis and size enlargement involved in the process development, scale-up and manufacturing of pharmaceutical drug products in industry (conventional / advanced nanotechnology based). In addition to the container/closure systems, some of the packaging processing methods are covered. Moreover, the vision about designing a quality product and its manufacturing process to consistently deliver the intended performance of the product to meet patient needs is discussed by applying Quality-by-Design principles.
Bachelor of Pharmacy - PharmD
1.1 Outline the construction of some unit operations used in pharmaceutical manufacture as mixing, size reduction, emulsification, centrifugation, size enlargement and pharmaceutical packaging and the factors affecting each process.
1.2 Identify essential ideas, aspects, advantages and disadvantages related to different pharmaceutical unit operations.
1.3 Outline the construction and role of each part of different equipment used in pharmaceutical manufacture and their optimal applications.
2.1 Recommend the proper technique and equipment for the production of pharmaceuticals
2.2 Judge on product quality according to the selected equipment.
2.3 Solve problems associated with different unit operations.
4.1 Improve skills within a setting of self-learning and appreciate the need for independent life-long continuing education in addition to team work.
4.2 Practice numeric and other computations including use of units, mathematical functions, modes of data presentation and presentation skills.
4.3 Keep up with pharmaceutical literature and with new developments of the pharmacy profession and pharmaceutical industry.
Aulton, Michael E., and Kevin M.G. Taylor. Aulton's Pharmaceutics: The Design and Manufacture of Medicines. Elsevier Health Sciences, 2018.
| content serial | Description |
|---|---|
| 1 | Introduction to pharmaceutical technology. (Lecture) |
| 1 | Powder flow. (Practical) |
| 2 | Mixing: Concept and theory. (Lecture) |
| 2 | Particle size analysis (sieve analysis).(Practical) |
| 3 | Mixing: solid-solid mixing. (Lecture) |
| 3 | Mixing technique (V-shaped mixer).(Practical) |
| 4 | Mixing: solid/liquid and liquid/liquid mixing.(Lecture) |
| 4 | Aspirin preparation using dry granulation.(Practical) |
| 5 | Size Reduction: Concept and theory. (Lecture) |
| 5 | Aspirin QC test 01. (Practical) |
| 6 | Size Reduction: Equipment. (Lecture) |
| 6 | Aspirin QC test 02.(Practical) |
| 7 | Emulsification: Concept and theory. (Lecture) |
| 7 | Paracetamol preparation using the wet granulation technique. (Practical) |
| 8 | Emulsification: Equipment. (Lecture) |
| 8 | Paracetamol QC test 01. (Practical) |
| 9 | Centrifugation: Concept and theory. (Lecture) |
| 9 | Paracetamol QC test 02. (Practical) |
| 10 | Centrifugation: Filtration centrifuges.(Lecture) |
| 10 | Paracetamol QC test 03.(Practical) |
| 11 | Centrifugation: Sedimentation centrifuges. (Lecture) |
| 11 | Evaporation laws and calculation of rate of evaporation and mass of steam, part 1. (Practical) |
| 12 | Size enlargement: Concept and techniques. (Lecture) |
| 12 | Evaporation laws and calculation of rate of evaporation and mass of steam, part 2. (Practical) |
| 13 | Size enlargement: Wet and dry granulation. (Lecture) |
| 13 | Drying law. (Practical) |
| 14 | Size enlargement: coating and pelletization. (Lecture) |
| 14 | Oral discussion. (Practical) |
| 15 | Pharmaceutical Packaging: Packaging lines for different products. (Lecture) |
| 15 | Presentation discussion.(Practical) |
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